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USDA: Bird flu vaccine not good enough for outbreak

 
 



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Old 06-03-2015, 06:05 PM   #1
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Default USDA: Bird flu vaccine not good enough for outbreak

MINNEAPOLIS — The U.S. Department of Agriculture says a bird flu vaccine doesn't work well enough to approve it for emergency use against the current outbreak that's shaken the Midwest poultry industry.

USDA: Bird flu vaccine not good enough for outbreak
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Old 06-28-2017, 10:33 PM   #2
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Now there's a flu vaccine patch...

Needle-Free Flu Vaccine Patch Works as Well as a Shot
Jun 28 2017 - A press-on patch that delivers flu vaccine painlessly worked as well as an old-fashioned flu shot with no serious side effects, researchers reported Tuesday.
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People who tried out the patch said it was not difficult or painful to use, and tests of their blood suggested the vaccine it delivers created about the same immune response as a regular flu shot, the team reported in the Lancet medical journal. The hope is the vaccine will be cheaper, easier to give and more acceptable than a regular flu vaccine. “It was really simple. It’s kind of like a band-aid almost,” said Daisy Bourassa, a college instructor who tested the new vaccine for the study. “It’s not like a shot at all. If I had to describe it is maybe like pressing down on the hard side of Velcro. It is like a bunch of little teeny tiny stick things that you can feel but it’s not painful.”

The team at Georgia Tech, and a spin-off company called Micron Biomedical, have been working on the patch vaccine for years. This was the first test using real flu vaccine, and the results show it caused immune responses very similar to those elicited by vaccine administered by syringe. “There were no treatment-related serious adverse events,” Dr. Nadine Rouphael of the Emory University School of Medicine and colleagues wrote in their report. It was a phase 1 trial, meant mostly to show safety in just 100 volunteers. That’s not enough to show whether the vaccine actually prevented any cases of influenza. That will take a larger trial to demonstrate. “The results were great,” Rouphael told NBC News. “We were pleased to see that the immune response was excellent.” Rouphael’s team were the experts in vaccinating, and were recruited by the Georgia Tech team to actually test the experimental patch.

The tiny needle-like points on the patch are made out of the vaccine itself. When pressed into the skin, the needles dissolve, delivering the dried vaccine into the outer layer of the skin. This layer is loaded with immune system cells that are the first line of defense against invaders such as bacteria and viruses. These cells take up the vaccine and use it to prime themselves against a flu infection. The trial showed that people could use the patch without any help and liked it. It also showed they had an immune response to the patch, and did not have any serious side-effects from using it. If it continues to work well in tests, Rouphael said it might be possible to just let people buy the vaccine patches and take them home to use.

They’ll be much easier to ship around the country and the world than current vaccines, which must be carefully refrigerated. Bourassa is a fan of the idea. “I think it would be fantastic if this was something you could get and administer it yourself at home,” she said. “The reason why many years I don’t get a shot is that I don’t have time to wait in a line or whatever. It would be really awesome if I could order it and it would be delivered like Amazon Prime.” Biomolecular engineering professor Mark Prausnitz of Georgia Tech, who leads the team developing the patch vaccines, said the vaccine stayed stable for as long as a year at temperatures up to 100 degrees F. Conditions like that would completely spoil a regular flu vaccine. “It is also really neat how you can keep it at room temperature,” Rouphael said. “It really simplifies the way we do vaccines. This could be a game-changer.”

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